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Consequently, drug accumulation in the lungs is altered through the impairment of mucociliary clearance, reducing overall treatment efficacy, as shown in Fig
side effects are generally mild [14]
Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1
Through 4 study arms the following two comparisons were made: I) The direct inhalation of one dose from the clinical inhaler, according to the label instructions, was compared to the same dose aspirated into the PI and inhaled by the volunteers, following prompted instructions
