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In normal physiologic state, the brain parenchyma is only subject to nascent immune surveillance, however during inflammation, the elevated pro-inflammatory markers induce the increased expression of adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on the endothelial cells of the BBB (Varatharaj and Galea, 2017

doi: 10.1016/j.plefa.2008.04.006

Wang YD, Tan PP, Chang L, Yue ZM, Zeng CZ, Li M, et al