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Overexpression of p66 Shc leads to endothelial dysfunction, characterized by increased ROS production, elevated levels of E-selectin, and enhanced leukocyte transmigration across the human umbilical vein endothelial cell (HUVEC) monolayer [37]

A collateral problem is that L-DOPA's duration of action decreases, because as the population of dopaminergic neurons decreases, it is no more effectively taken up by the neurons, transformed in dopamine, and gradually released

scutellata colonies (n = 6)

10.1017/S1047951125000198 74 HerridgeM
