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Overall, citrulline supplementation improved endothelial function in most studies, particularly in FMD measures

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These include potential immunogenicity, undefined long-term biosafety profiles of novel nanomaterials, suboptimal drug loading/release kinetics, limited penetration into the invasive tumor margin, and overcoming the immunosuppressive/hypoxic/acidic TME

Supplementation is safe, effective, and commonly used in clinical and wellness settings, particularly in individuals with deficiency, fatigue, or increased metabolic demand