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In a diabetic nephropathy (DN) model, N-(carboxymethyl)-lysine (CML), a key component of advanced glycation end products (AGEs), has been confirmed to induce a decrease in CPT2 expression, thereby impairing mitochondrial FAO and ultimately promoting the development of RF [72]

Sequencing and data analysis Final libraries were sequenced on the Illumina NovaSeq 6000 platform (Illumina) to produce paired-end 150 bp reads using v3 reagents

The method of any one of embodiments 79-89, wherein the therapeutic agent is an otoprotectant

Genes Chromosomes Cancer 46:796804 Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo JA, Navarro G, San Jose-Eneriz E, Garate L, Cordeu L, Cervantes F, Prosper F, Heiniger A, Torres A (2007) Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia