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This Gs-biased profile may contribute to sustained receptor signaling with less desensitization, though the clinical implications of signaling bias in GLP-1 therapeutics remain an area of active investigation

J Med Chem 51(23):74427448 Kwon DH, Patel J, Lewis-shimmel M, Marro C, Vasilenco A (2015) Retention of glutathione-specific acidity and disruption of intracellular glutathione-redox homeostasis are associated with antibacterial activity in Pseudomonas aeruginosa

Terns Pharmaceuticals reports topline 12-week data from its phase 2 trial evaluating oral GLP-1 receptor agonist TERN-601 in obesity