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Novel approaches targeting enterohepatic cycling of bilirubin, such as non-absorbable binding agents, offer promising preventive strategies [10, 39]

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ex Tedlie (125500 mg/kg), which is used as a natural antidote for gastric poisoning in Southwest Nigeria, significantly ameliorated acute elevation of the liver enzymes and hepatotoxicity-associated histopathological lesions within the liver by activating natural antioxidants (flavonoid and alkaloid) ( Vitex doniana Sweet) for the treatment of liver-related diseases was also assessed in APAP-induced hepatotoxicity ( Vitex doniana Sweet

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