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The RGD-(KLAKLAK)2 and NGR-(KLAKLAK)2 were especially toxic to angiogenic endothelial cells leading to reduced tumor growth and metastases as well as prolonged survival

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Less urgent but still worth reporting: side effects that do not improve after seven days at any dose level, persistent diarrhea that interferes with daily activities, significant hair thinning (which can occur during rapid weight loss phases and may relate to nutritional deficiencies rather than medication directly), mood changes including increased anxiety or depression, and hair loss patterns that seem disproportionate to weight loss speed

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