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In combination, the IC 50 value is reached at concentrations of EA and cryptotanshinone of 3.3 M and 0.68 M, respectively, similar to the MCF-7 cell line showing that combining competitive and non-competitive GST P1-1 inhibitors is optimal

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In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility