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The SHR group exhibited significantly higher MDA levels and notably lower SOD and GSH levels compared to the Norm group ( Supplementary Figure S1 )
Its main modes of action are the depletion and modulation of endogenous lymphocytes, conditioning of the microenvironment for improved CAR-T expansion and persistence, and reduction of tumor load
Biochem J 2010, 427: 171-178
Alternatively, the mitochondrial-free cytosolic fractions were extracted in 800 L of the defined extraction solution, incubated on ice for 5 min, and cleared by centrifugation at 17,000 g for 10 min
