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The mitochondrial pathway relies on the dynamic balance between pro-apoptotic proteins (e.g., BAX, BAK) and anti-apoptotic proteins (e.g., B-cell lymphoma-2 (Bcl-2)), reflecting regulatory imbalances in the Bcl-2 protein family [8]

from this it follows that, although all of them work together, perhaps protein antioxidants, which have enzymatic activity, such as superoxide dismutase, catalase, and glutathione peroxidase, constitute the first line of defense against the oxidative stress

100 In an immune-mediated liverbrain communication pathway, peripheral CCR2(+) monocytes migrate into the brain parenchyma in response to activated microglia expressing MCP-1/CCL2

doi: 10.1016/j.foodres.2022.112405 319 ZipporaA.-K.JosephA.HarrietD.ElvisA