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However, some conjugated metabolites can be directly cytotoxic because of their ability to inhibit enzymes important for cell viability, as well as by inhibition of the conjugating enzymes

2004;101(11):3780-3785.[DOI] 56

Cell, 2005)

Coarse control mechanisms including mitochondrial fission and fusion, changes in cristae structure, respirasome assembly, protein complex assembly, protein degradation and expression of nuclear and mitochondrial genes play intricate roles in modulating ATP output by mitochondria
