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In htgUGT1A -WT mice, a 17.4-fold CCL2 upregulation and a 10.8-fold TNF- mRNA induction was detected, whereas in the presence of SNPs transcriptional activation of CCL2 (6.4-fold) and TNF- (2.4-fold) was significantly less evident

ngr D, Jensen JE, Prescot AP, Stork C, Lundy M, Cohen BM, et al

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doi: 10.3389/fmicb.2026.1786250 Received 12 January 2026 Revised 27 February 2026 Accepted 09 March 2026 Published 14 April 2026 Volume 17 - 2026 Edited by Gregory Marczynski, McGill University, Canada Reviewed by Alan Leonard, Florida Institute of Technology, United States Andrei Kuzminov, University of Illinois at Urbana-Champaign, United States Updates Copyright 2026 Norris, Herrick and Kohiyama