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6 studies scored three points, and the remaining 4 scored five points, indicating medium and high-quality studies, respectively
Plasma DSIP levels follow a circadian rhythm, typically decreasing at sleep onset and showing inverse correlations with rapid eye movement sleep phases
Barrier Disruption by Specific Microbes Intestinal pathobionts are often overrepresented in the microbiota of patients with inflammatory disorders, where they accelerate systemic inflammation by translocating across the epithelial barrier to reach extraintestinal tissue ( Figure 1 )
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