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doi: 10.1111/jgh.12735
NFE2L2 is typically destined to be ubiquitinated by Kelch-like ECH-associated protein 1 (Keap1), a component of the Cullin 3 (CUL3)-based E3 ubiquitin ligase complex, and is degraded by the ubiquitinproteasome pathway within the cytoplasm [42]
Occasional vomiting , typically associated with rapid dose escalation
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