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It has been shown that PAEs with longer alkyl chains are more difficult to be degraded than those with shorter alkyl chains 26,27

CRC is the third most commonly diagnosed cancer in the world (38) and has a higher prevalence in acromegalic patients with respect to the general population (3941), reducing the responsiveness of cells to Transforming Growth Factor Beta (TGF) (42), enhancing the anti-apoptotic effects of both Cyclooxygenase-2 (Cox-2) (43) and Bcl2 Like 1 (Bcl-X L) (44), and enhancing the expression of the pro-angiogenetic Vascular Endothelial Growth Factor (VEGF) (45, 46)

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