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Devi N, et al

The neurovascular unit uncoupling initiates glial activation, neuronal apoptosis, blood-retinal barrier leakage, and ischemia, shifting the understanding of DR from a solely vascular disorder to a neurovascular one where early NVU impairment predicts functional deficits like reduced contrast sensitivity and progression to vision-threatening complications (34)

The 9mg group achieved 26.4%, suggesting that the 9mg dose offers nearly comparable efficacy with a potentially better side effect profile