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In kidney aging studies, it protected renal tubular epithelial cells, reduced renal inflammation, and improved renal function
Importantly, NNMT is a dominant component of the gene expression signature for sarcopenia, overexpression of which could lead to significantly reduced levels of NAD+ and associated declines in muscle mass, strength, and function that accompany aging
Additionally, mutations affecting vitamin B 12 transport and intracellular metabolism have been identified (17)
