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10.1128/mBio.00768-21 93 SunH.OlsonK

Its variable composition, structure, and dynamics can regulate genomic processes, influencing the binding capacity of transcription factors and their ability to carry out normal functions such as DNA repair and replication

Activated fibroblasts secrete a significant amount of collagen fibers at the periphery of the granuloma, forming a dense capsule that ultimately creates the three-layer pathological structure of classic gout stones: the inner MSU crystal core, the middle chronic inflammatory granuloma zone, and the outer fibrous capsule

Therefore, metal ions can only enter and exit the brain via transporters on the endothelial cells