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Emodin suppresses cancer growth by regulating the processes of necroptosis, autophagy, ferroptosis and uncoupling Emodin demonstrates anti-cancer activity against prostate, renal, glioma, liver, colon cancers, and melanoma by inducing necroptosis, autophagy, and ferroptosis through various signaling pathways [451, 452]

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Maggio 2013
4.3 Creating potassium/calcium channels by ORF3a One of the important capabilities of the viral ORF3a protein is the ability to create ion channels that decrease the concentration of K i + and increase Ca i 2+ in the cell (3)