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Under normal conditions, opiates suppress activity in the locus coeruleus, producing calmness and sedation
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Tirzepatide Tirzepatide targets both GIP and GLP-1 receptors, producing 20-22% body weight loss in important trials
[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Bonomi F., Pagani S., Cerletti P., Cannella C
