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Selected ABR genes from the heat map analysis that were enriched in visit 3 for both placebo and probiotic groups for aminoglycosides and beta-lactams were linked to various members of the family of Enterobacteriaceae using the Comprehensive Antibiotic Resistance Database, CARD 17 as shown in Supplementary Fig
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Further support for these findings came from an ex vivo skin model, which also showed a notable increase in collagen 4 synthesis at the dermal-epidermal junction when exposed to the optimized GHK-Cu and LMW HA mixture
