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Description
Traditionally, the high GSH content in lens is believed to protect free thiols, which allows the structural integrity and/or proper biological functioning of various enzymes to be maintained 28

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However, the most fundamental approach remains the reduction of sources and exposure to environmental pollutants

While several inhibitors of PHGDH and SHMT have been identified, many have not progressed to clinical trials due to unfavorable pharmacokinetic profiles, their recent development, or inadequate preclinical data [151]
