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Breakthroughs in cell densities, doubling times, and bioreactor efficiency have demonstrated the potential for cost reductions, with one optimized system lowering costs from $437,000 to $1.95/kg (Risner et al
The JOSD2-mediated deubiquitylation of aldolase A, and in particular PFK-1, directly results in increased flux of glucose into the glycolytic pathway
only a dramatic GSH:GSSG ratio decline (i.e., from 100:1 to 1:1) would result in a 50% conversion of PSH into PSSG
