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The experience of many centers is that the majority of patients with neonatal-onset methylmalonic acidemia or a severe phenotype have serious problems with poor feeding and vomiting that they cannot maintain adequate nutritional intake without the use of gastrostomy tube feedings

10 To determine the concentration of TMAO, liquid chromatography coupled with tandem mass spectrometry and automated nuclear magnetic resonance spectrometry are most often used

Gary Gonzalez, MD, in October 2024

In comparison, the proportion of CD8 + reached the initial level within 24 h pi , remained there until 72 h pi , and reached a significantly lower level compared to the baseline at 7 d pi , which was maintained until the end of the trial