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Despite its strength, the Achilles remains vulnerable to overuse injuries and degenerative conditions due to limited blood supply in its mid-portion

Antioxidants 13(6):657 Sakai R, Ukai W, Sohma H, Hashimoto E, Yamamoto M, Ikeda H, Saito T (2005) Attenuation of brain derived neurotrophic factor (BDNF) by ethanol and cytoprotective effect of exogenous BDNF against ethanol damage in neuronal cells

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Their mechanisms of action, which include the induction of oxidative stress, modulation of apoptosis, inhibition of telomerase, disruption of cell cycle progression, and interference with oncogenic signaling pathways, make them attractive candidates for cancer treatment
