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Oxidative stress, resulting from an imbalance between free radical production and the bodys antioxidant defenses, is a major contributor to aging and the development of various diseases (53)

Technical report

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Although some of these controversies are clearly based on methodological problems and plain misinterpretation of the data, more recent studies demonstrate that multiple signaling mechanisms dependent on the experimental conditions in animals or specific circumstances in patients, can lead to different modes of APAP-induced cell death, which is the topic of this critical review, which is based on our extensive experience with this topic and the pertinent literature