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This bidirectional regulatory mechanism provides a new perspective for understanding the pathophysiology of ECD and offers potential targets for developing new therapeutic strategies

352 A bisubstrate inhibitor comprises two covalently linked fragments, each binding to a substrate or cofactor element, potentially mimicking the ternary transition state of a bireactant-catalyzed reaction

Retrieved 5 November 2013

TRANSCRIPTIONAL UP-REGULATION OF NRF2 GENE BY ONCOGENE-DEPENDENT SIGNALING Because the degradation process primarily regulates the level of Nrf2 protein, there have been a few studies concerning the transcriptional control of the Nrf2 gene