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Peptide and protein antigens require distinct antigen-presenting cell subsets for the priming of CD4+ T cells

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demonstrated that GABA (1.5 gr/kg/day, IP) normalized hyperglycemia, improved insulin sensitivity (measured by insulin clamp), reduced liver glucagon receptor mRNA (but not glucagon levels), and increased muscle GLUT4 translocation to plasma membrane as well as GLUT4 mRNA expression (48)