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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

This conversion depends on adequate methylation, making efficient MTHFR function essential

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Nonetheless, while circadian clock modulation can have effects on sleep timing and structure, the effects of this modulation on sleep require direct measures, such as electroencephalogram, actigraphy, and/or polysomnography