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COPPER DYSREGULATION RELATED TO ATP7B GENETIC ISSUES IN WILSON DISEASE Excessive hepatic copper deposition in Wilson disease results from impaired biliary excretion of excess copper due to dysfunction of the ATP7B gene [20,21,24,27]

The Sirtuin Signaling Pathway mediates CR-responded cancer-associated networks This pathway regulates cancer cell metabolic reprogramming in glucose-poor environments (71)

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