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An analog of flavokavains was observed to inhibit LPS-induced pro-inflammatory expression of iNOS, TNF-, IL-1 , and IL-6 in murine macrophages in a manner superior to flavokavains A and B [57]
However, the precise molecular mechanisms linking inflammation to pain amplification remain unclear
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Although VDZ did not appear to significantly alter lymphocyte populations in colonic biopsies by CITE-seq, subsets of inflammatory MNPs and stromal cells trended lower in UC-VDZ patients, with a concomitant expansion of some epithelial subsets
