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"You will be defended against a future infection because the type of immunity you're raising is very, very specific it's exquisitely specific for the particular agent you're worried about," Hancock said

These include replicative exhaustion due to telomere shortening, DNA damage, oncogene activation, mitochondrial dysfunction, metabolic stress, proteotoxic stress, and exposure to certain inflammatory mediators or mitogens [49]

particularly, studies based on children with early diagnosis showed increased abundance of Bacteroidetes and Streptococcus mitis, while healthy controls showed higher prevalence of butyrate producers bacteria [60]

Chem Commun 49:63136315 Aguilera G, Colin-Gonzalez AL, Rangel-Lopez E, Chavarria A, Santamaria A (2018) Redox signaling, neuroinflammation, and neurodegeneration