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In comparison to the growth factor protocol, the small molecules appear to be a cheaper and simpler logistical approach for producing HLCs, but an objective comparison demonstrates that a larger number of components are required in the SM protocol (Siller et al., 2015
One important limitation to cryotherapy is that there is no visual endpoint that lets you know when enough treatment has been performed

The problem isn't that we look down on you, the problem is that you need to grow up
The procedure will take about half an hour
