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Notably, extracellular lactate levels typically rise during infections, suggesting that pathogenic bacteria may use protein lactylation to enhance toxin-mediated virulence (Wang et al., 2024)

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548 Furthermore, the silencing of METTL1, which also methylates tRNAs at the variable loop of several tRNAs, has been shown to increase the sensitivity of cancer cells to 5-FU by increasing cell death 555,556 (Fig