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Cortex 99:213223
10.17305/bjbms.2020.4711 Bosn J Basic Med Sci
By the end of the study, all ADA positive subjects were positive for neutralizing antibodies to the TL1A binding domain, and 7 of 12 were positive for neutralizing antibodies to the TNF binding domain, suggesting that the observed loss of exposure was primarily due to neutralizing anti-AMG 966 antibodies that competed for binding with the anti-idiotype antibodies used in the PK assay ( Table 2 )
to date, only one randomized double-blind placebo-controlled trial has been reported and it was conducted exclusively in men with AGA
