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A standardized scoring system was followed to assess CDI-associated histology injuries in intestinal tissues, and scores were evaluated across the groups based on epithelial damage, mucosal edema, and neutrophil infiltration 24

Setmelanotide has poor aqueous solubility, but the use of PEG excipients can worsen injection site reactions ( Table 1 ) ( In conclusion, setmelanotide is a very effective therapeutic for patients with genetic disruptions in melanocortin signaling pathways, primarily those with low levels of endogenous agonists for this system

Using streptavidin-alkaline phosphatase conjugate and a biotinylated secondary antibody, immunohistochemistry was carried out on the sections after the primary antibodies had been incubated for an overnight period

Annu Rev Pharmacol Toxicol (2009) 49:12350
