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doi: 10.3389/fendo.2022.1011669 110 BeghiniASammartinoAMPappZvon HaehlingSBiegusJPonikowskiPet al
The first vertebrate evidence of innate immune memory dates back to 1986, when researchers injected an avirulent, non-germinating strain of Candida albicans (PCA-2) into Rag1 / mice lacking mature T and B cells, these mice exhibited protection against subsequent lethal systemic C
Jamieson, 1998)
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