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349 Similarly, mutations in valosin-containing protein (VCP), a multifunctional AAA-ATPase essential for extracting ubiquitinated proteins from cellular structures and directing them toward degradation, cause multisystem proteinopathies that include ALS, FTD, and inclusion body myopathy

In a pilot study, six patients with advanced PD who received unilateral implantation of RPE cells had an average improvement of 48% in the off-period motor score after one year [69]

The Arabidopsis APX1 protein has five Cys residues, of which two (Cys32 and Cys49) are S -nitrosated (Yang et al

We detail the roles of key molecular chaperones across cytosolic, mitochondrial, and endoplasmic reticulum compartments, emphasizing their collaborative actions in protein folding and quality control
