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For documentation of usage parameters and a copy of the corresponding local cover article a57775, see Local Cover article

It is not approved for therapeutic use in humans, and no large-scale clinical trials have been conducted to evaluate its safety or efficacy as a medication

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First of all, baseline folic acid levels were different between studies (7.7 ng/mL for CSPPT renal sub study, 15 and 16.5 ng/mL for DIVINe and HOST study respectively) corroborating the hypothesis that beneficial effects of folic acid supplementation on renal outcomes could be stronger in patients with low folic acid level at baseline