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Furthermore, relevant and recent examples of novel cereblon-based PROTACs will be presented and the main results obtained from their biological evaluation will be analyzed

Pull-down assays can employ various tag-based affinity systems, including GST, 6xHis, MBP, and avidinbiotin arrangements

We calibrate and validate the model using experimental measurements, at different postnatal days up to PN28, from control mice and from the rd1 mouse model for the disease retinitis pigmentosa (RP)

Reduced levels of zinc can impair the pancreass ability to synthesize and secrete insulin and diminish the uptake of glucose by peripheral cells, leading to the development of insulin resistance, a hallmark of diabetes mellitus [5]