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It also limits the drugs impact on histamine, acetylcholine and norepinephrine, so the side effects are less

Acta 1863 , 24222435 (2016)

Akkus E, Carrier S, Rehman J, Breza J, Kadioglu A, Lue TF

MAOIs raised safety concerns due to their dietary and drug interactions (serotonin syndrome/toxicity, sympathomimetic drug interactions, and dietary tyramine interactions) (Grady and Stahl 2012), while both MAOIs and TCAs were associated with higher cardiac side-effects comparing to other ADs (Spindelegger et al
