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Normally binding of PDGF-BB to PDGFR results in PDGFR dimerization, tyrosine autophosphorylation, and subsequent activation of extracellular signalregulated kinase (ERK), Akt, GSK-3/, and WNK1 intracellular pathways (Smyth et al, 2022)
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Mandal PK, Saharan S, Tripathi M, Murari G. Brain glutathione levels--a novel biomarker for mild cognitive impairment. Biol Psychiatry. 2015;78(10):702-710. doi:10.1016/j.biopsych.2015.04.005
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