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Barajas et al., / ApoE / mice developed reduced aortic atherosclerosis as compared to Nrf2 +/ ApoE / (Barajas et al., +/+ ApoE / controls (Sussan et al., 2008

Wynn TA (2011) Integrating mechanisms of pulmonary fibrosis

10.1038/s41587-023-01747-2 Nat

This fundamental difference implies that natural compounds might require less frequent dosing to achieve a continuous neuroprotective effect, whereas levodopa's dosing frequency is strictly determined by its short pharmacokinetics [101]
