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B12 deficiency can lead to negative side effects
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Patients using metformin for prolonged periods may, therefore, need initial screening with intermittent follow-up, particularly since vitamin B 12 deficiency has similar symptoms to diabetic neuropathy which itself affects 40 50% of patients with T2DM at some stage
Finally, soluble intra and extracellular forms of CD38 have also been described (Figure 3)[38-39, 57]
