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Doses up to 60mg/kg per day produced no observable toxicity

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To enable genetic associations to be interpreted in units of weight rather than BMI % , we also defined a corresponding weight phenotype, defined as the change in weight from baseline in kilograms

Pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) expressed on epithelial cells interact with microbiota-derived pathogen-associated-molecular patterns (PAMPs) such as lipopolysaccharide (LPS) to activate myeloid differentiation factor 88 (MYD88)-dependent signaling