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However, further studies are still needed to optimize its clinical application, including dosage form improvement, combination therapy strategies and long-term safety assessment

Nutritional deficiency is caused by a lack of the vitamin in the diet, whereas acquired deficiency occurs when the intestinal absorption of the vitamin is interfered with by diseases and conditions such as pernicious anemia (an autoimmune disorder affecting intrinsic factor protein produced by gastric parietal cells), chronic atrophic gastritis, Crohn's and celiac diseases, gastric bypass surgery, and medications such as metformin, gastric acid secretion blockers (i.e., proton-pump inhibitors and H2-receptor antagonists), and others (2, 3)

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Well, the injection liquid form of vitamin B12 is specially developed for those that cannot absorb vitamin B12 orally