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(2017) transduced cells derived from a 2-year-old PA patient with Dox inducible system coding for simian vacuolating virus 40 large T antigen (SV40-TAg, Figure 2 )

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The novel peptide neuropeptide W (NPW), which has 23 (NPW23) or 30 (NPW30) amino acid residues, was proposed as a mediator in controlling the neuroendocrine response to stress, because stress induction stimulates NPW-containing hypothalamic neurons and central administration of NPW in rats activates the hypothalamus-pituitary adrenal (HPA) axis (Niimi and Murao 2005)

In addition, the high costs of the preparation technology used and certain stability problems can create difficulties in the clinical expansion of these types of formulations [219,221]