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SAM administered orally or by injection has been investigated as a treatment for liver diseases, osteoarthritis, and depression.6 The benefits bestowed by SAM may be due to its role as a methyl donor in biochemical processes governing lipid homeostasis, DNA stability, gene expression, and neurotransmitter release

This mechanism can be beneficial in injuries, as higher growth factor activity correlates with faster healing 3

The SAR studies examined around structure 41 showed the aromaticity of the ring B of compound 41 appears essential for activity, as replacement of ring B with cyclohexyl ring (compound 42b ) losses the inhibitory activity of melanin synthesis in B16 cells