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Although the efficacy of GHK-Cu has been recognized, there are certain limitations in its application, such as higher cost, thicker skin feel, and intolerance to high temperatures

Additionally, cytosolic hydrogen peroxide (H 2 O 2 ) acts as the primary form of ROS responsible for stabilizing HIF-1

Thus, tailored approaches for the identification and treatment of senescence in specific tissues will be necessary.257 Dosing and Timing: Finding the right dosing schedule for senolytics and senomorphics is critical to their success in clinical practice

This study highlights the importance of gaining knowledge about changes in cell structure to better understand the cognitive effects of mild bTBI [285]